HPS2194-95
124123-15-5
默认>95%HPLC,若需其他规格请洽询
产品编号 | 规格 | 货期 | 销售价 | 折扣价 | 数量 | 操作 |
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HPS2194-95 | 默认>95%HPLC,若需其他规格请洽询 |
25天
|
敬请询价 | 敬请询价 |
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名字 | PACAP-38 (human, mouse, ovine, porcine, rat) trifluoroacetate salt |
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序列(三字母) | H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH₂ trifluoroacetate salt |
序列(单字母) | HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH₂ |
CAS# | 124123-15-5 |
分子式 | C₂₀₃H₃₃₁N₆₃O₅₃S |
分子量 | 4534.32 |
纯度 | 默认>95%HPLC,若需其他规格请洽询 |
合成方法 | Synthetic |
储存条件 | -20 ± 5 °C |
应用 | Alzheimer´s Disease |
描述 | Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin. |